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Researchers identify connection between pulmonary hypertension and cognitive impairment

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Researchers identify connection between pulmonary hypertension and cognitive impairment

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University of Pittsburgh and UPMC researcher-clinicians have uncovered why many pulmonary hypertension patients report symptoms of cognitive decline.

The new study, published in the Journal of Clinical Investigation, links specific brain abnormalities in pulmonary hypertension to the same inflammatory processes that drive the disease in the lungs and heart, suggesting that cognitive decline may be present in other vascular and inflammatory conditions beyond pulmonary hypertension. The findings also point to a biological marker that could be used to screen people for future cognitive issues.

Millions of people are affected by pulmonary hypertension, which causes high blood pressure in the blood vessels of the lungs. Common symptoms include shortness of breath, chest pain and lightheadedness. The researchers found that cognitive issues such as impaired executive function and memory problems are often also present in pulmonary hypertension, and they have uncovered a biological reason for the phenomenon.

, Vitalant chair in vascular medicine and director of the Vascular Medicine Institute and Center for Pulmonary Vascular Biology and Medicine at the Pitt School of Medicine and UPMC.



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