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New research led by Monash University shows a multi-domain dementia risk reduction program delivered by general practice nurses can improve estimated dementia profiles in middle-aged adults, offering a practical new model for proactive brain health.

Published in The Lancet Regional Health—Western Pacific, the study evaluated more than 403 adults aged 45 to 65 years with modifiable risk factors across 31 Australian general practices. It found that a 12-month, nurse-led intervention involving the HAPPI MIND app produced a statistically significant improvement in participants' dementia risk scores compared to standard care.

Senior author associate professor Johnson George, from the Center for Medicine Use and Safety (CMUS) at the Monash Institute of Pharmaceutical Sciences (MIPS), said embedding strategies into primary care is key to long-term community health.

"Think of it as a personalized health check and coaching program for brain health," George said. "The nurse helps people identify areas they can work on and turn advice into practical targets, while the purpose-built self-monitoring and goal-tracking app helps them track progress between appointments."

Lead author and CMUS research fellow Dr. Muhammad Rehan Sarwar said Australian general practice provides a crucial opportunity to help middle-aged adults take action.

"The findings suggest that personalized support through general practice may help people act on modifiable risk factors relevant to brain health," Sarwar said.

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