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An Upper-South region of Texas including San Antonio and Bexar County had the state's highest hysterectomy-corrected incidence of endometrial cancer and the largest increase over time, a study led by scientists at The University of Texas at San Antonio Health Science Center and the National Cancer Institute showed.

Endometrial cancer is the most common gynecologic cancer in the United States. And while several types of cancer are declining across the country, endometrial cancer is on the rise, especially in South Texas.

This type of cancer often is diagnosed early and is highly survivable, but both endometrial cancer incidence and mortality rates have increased sharply over the past 20 years. The recent study published in the journal Cancer Epidemiology provides a comprehensive examination of regional differences in endometrial cancer incidence and survival across Texas.

Principal investigator Edward R. Kost, M.D., professor of gynecologic oncology in the Department of Obstetrics and Gynecology at the Long School of Medicine and gynecologic oncologist at the Mays Cancer Center at UT Health San Antonio, said the goal is to figure out why endometrial cancer rates are rising and which populations are most affected.

"The mission of the Mays Cancer Center is to reduce the burden of cancer in San Antonio, South Texas and beyond," Kost said. "To do that, we need to understand the cancers that affect our local population."

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