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Researchers have outlined a plan for slowing aging by targeting one of the body's most important cellular communication systems. In a new paper published in Frontiers in Science, scientists describe how novel therapies that modulate GPCR signaling could one day help delay multiple age-related diseases at once—potentially extending healthy years of life.

GPCRs are widespread throughout the body and regulate many essential biological processes. Age-related changes in GPCR signaling are linked to multiple hallmarks of aging and many major chronic diseases. The authors propose that therapies designed to rebalance GPCR signaling across tissues could therefore help counter some of the key biological processes that drive aging and age-related disease.

Senior author Stuart Maudsley from H. Lee Moffitt Cancer Center in Florida said, "What's most exciting about this network-level GPCR approach is its ability to influence many of the biological systems that change with age at the same time."

This network-level approach—targeting multiple GPCR pathways across the body rather than a single receptor or disease—could give rise to personalized treatments based on individual aging biomarkers, the researchers say, as well as advanced strategies that modulate GPCR signaling across different tissues and pathways.

These interventions could also complement other emerging longevity strategies—such as metabolic therapies, regenerative medicine and treatments that reduce chronic inflammation—to help preserve health and function by acting on several aging processes in parallel.

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