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Disability burden linked to alcohol-related cirrhosis and heart failure projected to rise sharply by 2050

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Disability burden linked to alcohol-related cirrhosis and heart failure projected to rise sharply by 2050

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The disability burden associated with alcohol-related cirrhosis complicated by heart failure is projected to rise substantially by 2050 across Central Europe, Eastern Europe and the United States (US), according to new research presented at UEG Week 2026.

Researchers analyzed Global Burden of Disease data from Central Europe, Eastern Europe, Western Europe and the U.S. between 1990 and 2023, examining years lived with disability (YLD)—a measure of time spent living with ill health or disability—by age and sex. They also modeled how the burden could change through 2050.

The study found that the burden has already increased considerably across all four regions since 1990, with particularly pronounced increases among older adults and men. By 2050, further rises of around 50–67% are projected in the U.S., Central Europe and Eastern Europe, while Western Europe is projected to see a 19% decline.

Alcohol-related liver disease remains a major public health challenge. The WHO European Region has the highest level of alcohol consumption globally, and alcohol is causally linked to more than 200 diseases and health conditions, including liver cirrhosis and cardiovascular disease.

Scientists are increasingly exploring the interrelationship between the heart and liver along shared disease trajectories, often referred to as the 'heart-liver axis.' In Europe, alcohol is also the most common cause of death from liver disease.

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