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Women with the inherited cholesterol condition familial hypercholesterolemia may be at a slightly higher risk of developing preeclampsia, a pregnancy condition that can cause serious complications, according to a new study in the European Journal of Preventive Cardiology.
Familial hypercholesterolemia (FH) causes lifelong high cholesterol and substantially increases the risk of heart disease. It affects approximately 1 in 200 to 300 people, although most are undiagnosed.
People with hypercholesterolemia have elevated levels of total cholesterol in the blood, particularly LDL (or 'bad') cholesterol. Some studies have found links between the noninherited form of hypercholesterolemia and differences in women's reproductive health and pregnancy outcomes. However, there has been uncertainty because it is challenging to separate the effects of hypercholesterolemia and lifestyle-related factors.
The new observational study compared 484 women with FH and 968 matched controls, aged 40 and over, in the Netherlands and Norway. Researchers found similar reproductive health and pregnancy outcomes, but there was a higher prevalence of preeclampsia among women with FH (11% vs. 7% among the control group).
Preeclampsia is characterized by high blood pressure in pregnancy in combination with organ damage and it can cause complications, including slower growth during pregnancy and premature birth. In some instances, complications can be serious and potentially life-threatening. There is no cure, but treatments and care plans can help women manage symptoms and keep the baby as healthy as possible.
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