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Two 'forever chemicals' associated with higher risk of aggressive breast cancer in analysis

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Two 'forever chemicals' associated with higher risk of aggressive breast cancer in analysis

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Women with higher blood levels of two common per- and polyfluoroalkyl substances, also familiarly known as PFAS, were more likely to develop estrogen receptor-negative, or ER-negative, breast cancer, according to a new study by the National Institutes of Health (NIH), part of the U.S. Department of Health and Human Services (HHS). PFAS are a large group of chemicals used in common consumer products. Often referred to as "forever chemicals," PFAS do not break down easily in the environment and can remain in the body for years.

The study found that higher blood plasma levels of two of these substances, perfluorooctanoic acid (PFOA) and perfluorooctanesulfonic acid (PFOS), were associated with a higher incidence of ER-negative breast cancer. No clear association was observed between the two chemicals and breast cancer risk overall.

"Women deserve clear answers about how chemicals in their environment may affect their health," said HHS Secretary Robert F. Kennedy Jr. "This NIH study links two forever chemicals to a higher risk of ER-negative breast cancer and demands further investigation. Under President Trump's leadership, we will pursue the evidence, confront environmental health risks, and give women the information they need to protect their health."

ER-negative tumors lack receptors that allow the hormone estrogen to help cancer cells grow. Compared with breast cancers that respond to the hormone estrogen, ER-negative breast cancers tend to be more aggressive and have worse outcomes.


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