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Combined estrogen and testosterone therapy increases lumbar spine bone mineral density

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Combined estrogen and testosterone therapy increases lumbar spine bone mineral density

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Bone mineral density significantly decreases during and after menopause due to dropping levels of estrogen. Historically, estrogen therapy has been prescribed to help protect bones, but a new study suggests that the addition of testosterone therapy may improve results compared with using estrogen alone. Results of the study were presented at the 2026 Annual Meeting of The Menopause Society in San Diego Oct. 20–24, 2026.

Research has shown that women can lose 10% to 20% of their bone density in the first five to seven years following menopause. This rapid thinning raises the risk of developing osteopenia (low bone mass) and osteoporosis (weak, brittle bones prone to fractures). There are multiple proven and effective methods to help protect bone health, including weight-bearing and resistance exercises, adequate daily intake of calcium and vitamin D, and hormone therapy.

Standard hormone therapy consists of using estrogen to significantly lower the risk of spine and hip fractures. But a new study suggests there may be a way to build on the foundation of estrogen therapy to get better results.

1 years. Dual-energy X-ray absorptiometry (DEXA) scans were used to measure bone mineral density at baseline, after at least one year of estrogen therapy alone and after at least one year of estrogen plus testosterone therapy.



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