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Very severe long COVID linked to differences in lung and mouth microbiomes

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Very severe long COVID linked to differences in lung and mouth microbiomes

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People with long COVID have distinct differences in the mix of bacteria that live in their mouths and lungs, according to a study of more than 700 people published in the European Respiratory Journal. The research also shows that these differences in the lung microbiome are linked to respiratory symptoms, as well as the cognitive and digestive problems known to occur in long COVID.

Researchers say their findings may shed light on why some people develop long COVID and could point to new ways to treat the condition.

The lead author of the study was Dr. Daniela Alferes de Lima Headley from the University of Dundee, U.K. She said, "We know that millions of people worldwide are still affected by long COVID and its cause is still unknown. Long COVID affects multiple organs.

"The microbiome is important to maintain health throughout the body, so it is a strong candidate for something that may contribute to long COVID. Prior studies have shown some changes in the gut microbiome with long COVID, but COVID is a lung disease and so it makes sense to look to see if the lung microbiome is changed in long COVID."

This research is part of PHOSP-COVID and included 771 people who had been treated for COVID-19 between February 2020 and March 2021 at one of 38 U.K. hospitals.

Researchers divided the participants into four groups based on how severe their symptoms were five months after being discharged from the hospital.


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