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A pilot study suggests that low doses of LSD may have different effects on sustained attention in women and men. The findings, presented at the ECNP annual congress in Munich, are preliminary, but they add to growing evidence that people may not all respond to psychedelic microdosing in the same way.

Microdosing means taking a very small amount of a psychedelic drug, below the level usually associated with a full psychedelic experience. Some people report using low-dose LSD in the hope of improving focus, concentration, productivity or mood, and there are also anecdotal reports of people using it to manage problems with attention. However, controlled scientific studies have produced mixed results, making it important to test these claims carefully.

A group of researchers from the University of Maastricht tested the responses of volunteers to microdosing. The randomized controlled study involved 48 healthy volunteers, including 24 women, with an average age of 36.9 years.

Participants were randomly assigned to receive either placebo or four low doses of LSD, each containing 15 micrograms, over a two-week period (typical psychedelic effects tend to appear with doses greater than 60 mcg). Neither the participants nor the researchers knew who had received LSD and who had received placebo until after the study was completed.

Researchers looked at three areas of mental performance: sustained attention, information processing and working memory. Participants completed tests at the start of the study, after the first dose, after the fourth dose and at follow-up.

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