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A study has revealed that resistance (weight) training not only preserves lean and muscle mass but also increases strength in people taking weight-loss medication. Published in Nature Medicine, the Tirzepatide and Resistance Exercise (T-REx) study is the first to show the effects of combining a GLP-1 medicine and resistance training on body composition, muscle mass, strength and a range of cardiovascular health measures.

Drugs such as semaglutide (Ozempic and Wegovy) and tirzepatide (Mounjaro) are commonly used for weight loss and have been found to improve chronic health conditions, reduce risk of obesity-related cardiovascular diseases, and enhance quality of life.

Lead investigator Winthrop Professor Danny Green, from The University of Western Australia's School of Human Sciences and HealthSpan Institute, said resistance exercise should be part of the prescription when people are using a weight-loss drug such as tirzepatide.

The dramatic drop in body weight and fat mass delivered by GLP-1 medicines had raised questions about potential loss of lean and muscle mass, Green said. (Lean mass is your body weight minus your body fat mass and includes muscles, organs, bones, skin and body water, while muscle mass refers to the weight of muscle tissue in your body, which is mostly skeletal muscle.)

"Loss of lean mass, including muscle, is an inevitable part of weight loss by any method—whether through diet and exercise alone, or medical or surgical interventions," he said.

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