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Capturing a complete picture of what causes brain diseases from schizophrenia and Parkinson's disease to addiction has long been a challenge for scientists. But a growing body of evidence indicates that all seem related to the basal ganglia—a group of structures found in the center of the brain that control the body's movements, decision-making processes and habit formation.

Today, a large group of scientists from more than 50 institutions released the first comprehensive, multispecies atlas of basal ganglia cell types from humans, macaques, marmosets and mice. The atlas could help elucidate the key roles different cells play in determining the pathways that give rise to various brain diseases.

The journal Cell and other Cell Press journals published a package of 28 papers.

By building the research tool known as the NeMO Archive (Neuroscience Multi-Omic Archive), IGS researchers made it easy for scientists around the world to discover, analyze and integrate data across multiple studies and technologies. Including this new research, NeMO Archive houses genomic, transcriptomic, epigenomic and spatial transcriptomic data from more than 50 million brain cells.

"I've spent much of my career working to make scientific data openly accessible, because the real value of these large research efforts comes when scientists everywhere can build upon them," said contributing principal investigator Owen White, associate director of research collaboration and development at IGS and professor of epidemiology and public health at UMSOM.

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