Integrated academic health system BJC Health and independent non-profit provider St. Luke’s Hospital in Chesterfield, Missouri, announced that they have signed a Letter of Intent (LOI) for St. Luke’s to join BJC.

Founded in 1866, St. Luke’s operates a 493-bed flagship hospital in Chesterfield alongside more than 60 specialties and 30 outpatient locations across the greater St. Louis region.

The proposed affiliation follows a formal strategic evaluation led by St. Luke’s Board of Directors—chaired by Vincent Ferrari—and comes roughly one year after St. Luke’s closed its Des Peres Hospital amid rising standalone operational pressures.

Joining BJC Health connects St. Luke’s patients and clinicians to an enterprise system comprising nearly 50,000 employees, 27 hospitals, more than $1.5 billion in annual community investment, and an academic affiliation with WashU Medicine, Barnes-Jewish Hospital, St. Louis Children’s Hospital, and the Alvin J. Siteman Cancer Center.

Under the framework outlined in the Letter of Intent, BJC Health aims to preserve St. Luke’s community-focused care delivery while integrating its clinical footprint into BJC’s broader academic and tertiary infrastructure. For St. Luke’s patients, the affiliation is designed to create seamless referral pathways from primary and community-based settings into highly specialized WashU Medicine subspecialty programs.

To support long-term operational competitiveness in west St. Louis County, BJC plans to direct capital investments toward clinical technology and medical equipment upgrades, physical facility and infrastructure modernization, and physician recruitment and retention at St. Luke’s. Over the coming months, both organizations will conduct due diligence to negotiate a definitive agreement and initiate required state and federal regulatory reviews, with patient care and clinical schedules continuing uninterrupted during the transition.

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