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Men who use cannabis occasionally reacted more strongly to smoked cannabis than women with similar use habits, even though the amount of THC in their blood was about the same, according to a new study from UCLA Health. The findings run counter to earlier research suggesting that women are more sensitive to cannabis.

The study, published in Neuropsychopharmacology, is the first experiment designed to test how sex and frequency of use together shape the short-term effects of smoked cannabis. Researchers at the UCLA Center for Cannabis and Cannabinoids enrolled healthy adults, split evenly by sex and by how often they used cannabis: weekly or daily use.

In three separate sessions, each participant smoked placebo, lower-THC and higher-THC cannabis without knowing which they had received. Women in the study were not using hormonal birth control and were tested during the same phase of their menstrual cycle. The analysis found:

"Much of what we thought we knew about sex differences in cannabis effects came from animal research and from human studies that pooled data from different trials," said Dr. Ziva Cooper, the study's principal investigator and director of the UCLA Center for Cannabis and Cannabinoids.

"When we designed a study to look at sex and frequency of use at the same time, and controlled for hormones, the picture changed.

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