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Large-scale genetic study on Alzheimer's identifies new DNA risks

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Large-scale genetic study on Alzheimer's identifies new DNA risks

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A large-scale international study offers new insights for understanding Alzheimer's disease and developing future treatments. The University of Exeter–led PROTECT study was part of the research, led by Vrije Universiteit Amsterdam and published in Nature, which sheds clearer light on the role of immune cells within the brain, as well as several specific neuronal cell types.

The scientists identified 127 regions in human DNA associated with the risk of developing Alzheimer's disease—48 of which had not previously been mapped in this context. These findings provide researchers with a deeper understanding of the biological processes that contribute to the onset of the disease and may aid in the development of new therapies.

Professor Anne Corbett of the University of Exeter is the PROTECT study lead and said, "This exciting new genetic analysis has uncovered new information on how our genes influence our risk of Alzheimer's disease. We're delighted that the PROTECT-UK study contributed to these important new findings. PROTECT collects genetic samples from all participants through a simple at-home saliva sample. This data can then be combined with cohorts from around the world to help us to better understand dementia risk and how it can be treated."

Alzheimer's disease is the leading cause of dementia. The number of people living with dementia is expected to rise sharply worldwide, with projections suggesting more than 150 million cases by 2050.


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