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A research team led by the Joint University Institute for Sport and Health (iMUDS) at the University of Granada, in collaboration with the Granada Institute for Biomedical Research and the Biomedical Research Network Center, has studied the effects of combining intermittent fasting and supervised exercise in people with obesity as part of the TEMPUS project.

The study, published in the journal Nature Communications, shows that combining intermittent fasting and supervised exercise promotes greater weight and body fat loss, in addition to improving cardiorespiratory fitness in people with obesity, although no greater reduction in accumulated liver fat was detected compared with standard care.

The trial included 187 adults with obesity, approximately half of whom were women. The participants were randomly assigned to four groups: standard care, intermittent fasting, supervised exercise and fasting combined with exercise. For 12 weeks, all groups received education on the Mediterranean diet and physical activity.

In addition, those who practiced intermittent fasting concentrated their meals within an eight-hour window each day. The exercise groups followed a supervised program that combined strength training and high-intensity aerobic exercise.

The primary objective was to determine whether these strategies led to a greater reduction in liver fat—measured by MRI—and an improvement in cardiovascular health. The results showed that liver fat decreased in all four groups. However, no statistically significant differences were found between the interventions and standard care, nor among the three interventions themselves.

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