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Clinical trial explores potential brain health benefits of dietary supplement

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Clinical trial explores potential brain health benefits of dietary supplement

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A dietary supplement called urolithin A increased blood flow to the brain during mental activity in middle-aged adults with obesity, according to a University of Oklahoma study published in JAMA Network Open. The findings could help researchers better understand the relationship between the supplement, blood vessel function and brain health.

Obesity is associated with changes in blood vessel function that can affect circulation throughout the body, including the brain. Researchers wanted to determine whether urolithin A could improve blood vessel function in adults with obesity. To find out, they conducted a randomized clinical trial involving 50 adults aged 40 to 64. Participants received either 1,000 milligrams of urolithin A daily or a placebo for four weeks.

Researchers found that participants who took urolithin A experienced a greater increase in blood flow to the brain while performing a challenging memory task than those who received the placebo. The change was particularly apparent in the left dorsolateral prefrontal cortex, a region of the brain involved in working memory. However, the supplement did not significantly improve the function of blood vessels in the arm, and participants did not perform significantly better on memory tests. This is the first human study to report an effect of urolithin A on cerebrovascular function, the researchers said.

, an assistant professor in the Department of Nutritional Sciences at the OU College of Allied Health on the OU Harold Hamm Health Campus.


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