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Substance use disorder recovery, remission linked with genetic, psychosocial factors

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Substance use disorder recovery, remission linked with genetic, psychosocial factors

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A new study by researchers at the University of Illinois Urbana-Champaign highlights the importance of considering both psychosocial and genetic factors in patients' prognoses and intervention planning in their recovery from substance use disorders.

The study is novel in that it integrated multiple forms of data—including genetic data on heritable risk factors and statistics on the various psychosocial resources available to support individuals' recovery—to analyze 7,200 U.S. adults' probability of remission and relapse, said first author Janaka V. Kosgolla, a research scientist in the School of Social Work's Center for Prevention Research and Development.

Kosgolla, who co-wrote the paper with the center's director, Douglas C. Smith, used a data set from the National Institutes of Health All of Us Research Program that contained information on adults aged 18 or older who were treated for substance use problems between December 2020 and October 2023.

Eligible participants were identified from diagnoses, toxicology measurements, medications and treatment procedures for those with substance use problems other than nicotine, according to the study, published in the journal Addiction.

Addiction is a complex biological process, with individuals' risk increased by interactions among hereditary genetic variations and environmental factors, according to a news release on the National Institutes of Health website.

The current study is one of a few projects that integrated patients' genetic liability with recovery capital resources to measure an individual's probability of remission and relapse over time.


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