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Postop morbidity lower with laparoscopic versus open resection of colorectal liver metastases

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Postop morbidity lower with laparoscopic versus open resection of colorectal liver metastases

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For patients with colorectal liver metastases (CRLM), laparoscopic liver resection (LLR) is associated with lower postoperative morbidity than open liver resection (OLR), with similar long-term oncologic outcomes, according to a study published online Oct. 27 in the Annals of Internal Medicine.

Bram Olij, M.D., from Maastricht University in the Netherlands, and colleagues compared postoperative and long-term oncologic outcomes after LLR versus OLR for CRLM in a meta-analysis using individual participant data from eligible randomized clinical trials. A total of 761 patients were included (384 laparoscopic and 377 open).

The researchers found that compared with open surgery, postoperative morbidity was lower in patients assigned to laparoscopic surgery (19% versus 27%). Morbidity did not differ between the groups among patients who received preoperative systemic therapy (25% versus 24%). Ninety-day mortality was 1.8% and 0.8% after LLR and OLR, respectively. Overall survival and disease-free survival did not differ between the groups after a median follow-up of 93 months.

"The findings are consistent with the published trial-level reports from the included randomized studies and indicate that assignment to the laparoscopic approach is associated with lower postoperative morbidity and shorter hospital stays, whereas long-term oncologic outcomes were similar between groups," the authors write.

Bram Olij et al., Laparoscopic Versus Open Liver Resection for Colorectal Liver Metastases, Annals of Internal Medicine (2026). DOI: 10.7326/annals-26-02171



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