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IBD not linked to risk of hypertensive disorders of pregnancy overall

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IBD not linked to risk of hypertensive disorders of pregnancy overall

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Inflammatory bowel disease (IBD) is not associated with an increased risk of hypertensive disorders of pregnancy overall, but it is associated with an increased risk of preeclampsia, according to a study published in the September issue of the American Journal of Gastroenterology.

Lindsay M. Clarke, M.D., from Brigham and Women's Hospital in Boston, and colleagues used electronic health records in a single-center cohort study of singleton pregnancies delivered from 1998 to 2016. They examined whether IBD is associated with the risk of hypertensive disorders of pregnancy.

The study included data from 364 pregnancies (266 individuals) with IBD and 45,048 pregnancies (32,189 individuals) without IBD. The researchers found no association between IBD and hypertensive disorders of pregnancy overall. IBD was associated with increased odds of preeclampsia (adjusted odds ratio, 1.65), but not gestational hypertension. It was also associated with preterm delivery, small for gestational age and cesarean delivery (adjusted odds ratios, 1.87, 1.72 and 1.72, respectively), but not with other secondary outcomes.

"Given the increased risk of certain adverse perinatal outcomes within this population, this highlights the importance of proactive multidisciplinary care, including high-risk obstetricians," the authors write.

Lindsay M. Clarke et al, The Risk of Hypertensive Disorders of Pregnancy in Inflammatory Bowel Disease, American Journal of Gastroenterology (2025). DOI: 10.14309/ajg.0000000000003818



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