CONNECT WITH US
HealthTech

HealthTech

High-fat diets suppress enzyme in immune cells, promoting fat tissue inflammation in mice

Medical Xpress logo

Published on

Add as a preferred source on Google
High-fat diets suppress enzyme in immune cells, promoting fat tissue inflammation in mice

This article has been reviewed according to Science X's editorial process and policies. Editors have highlighted the following attributes while ensuring the content's credibility:

A group of innate immune cells, known as group 2 lymphoid cells (ILC2), are essential for maintaining a stable metabolism in adipose tissue. Obesity significantly impairs the number and function of ILC2 cells, leading to the progression of metabolism-related inflammation. Until now, it was unknown how ILC2 cells are disrupted in obesity.

Researchers at the University Hospital Bonn (UKB) and the University of Bonn have now discovered in obese mice that the key enzyme in fatty acid biosynthesis, known as acetyl-CoA carboxylase 1 (ACC1), is a crucial regulator for the maintenance and function of ILC2 immune cells in adipose tissue. The Bonn researchers thus provide an explanation for the adverse effects of inhibiting acetyl-CoA carboxylase in obesity. Their findings have now been published in the journal Cell Metabolism.

Recent lifestyle changes, such as reduced physical activity and increased consumption of energy-dense, processed foods, have dramatically increased the prevalence of obesity and diabetes worldwide. Although the development of obesity-related metabolic diseases is complex, it is primarily driven by persistent, low-grade inflammation, known as metaflammation. Adipose tissue harbors a wide variety of immune cells that help balance energy supply, blood glucose levels and lipid metabolism by promoting an anti-inflammatory environment. This balance is disrupted in obesity, leading to fundamental changes in adipose tissue.

ILC2 immune cells are involved in lipid metabolism, using free fatty acids to build cell membranes and promote cell growth.


Source link
Related Topics:HealthTech

Disclaimer

We strive to uphold the highest ethical standards in all of our reporting and coverage. We TheMorningPulse.fyi want to be transparent with our readers about any potential conflicts of interest that may arise in our work. It's possible that some of the investors we feature may have connections to other businesses, including competitors or companies we write about. However, we want to assure our readers that this will not have any impact on the integrity or impartiality of our reporting. We are committed to delivering accurate, unbiased news and information to our audience, and we will continue to uphold our ethics and principles in all of our work. Thank you for your trust and support.