The Hokage is a prestigious position in Konoha that can only be assumed by the most powerful, reliable, and wise individual in the village. Over the years, some legendary figures have taken over the position of Hokage, including the likes of Hashirama Senju, Minato Namikaze, Hiruzen Sarutobi, and even Naruto Uzumaki, among many others.
Generally, the Hokage is the strongest shinobi of the village, but that's not to say that all strong ninjas of a village end up becoming the Hokage. At times, there are individuals who, despite reaching levels far greater than the Hokage, never end up becoming the Kage themselves. In the new age of the shinobi, that is, in the Boruto era, there are quite a few ninjas in Konoha that have already surpassed the level of an average Kage. Many others have the potential to surpass this stature as well.
Boruto has grown so strong that even the Gods of the Naruto world would lose in a 1 vs. 1 battle with him.
In the post-timeskip events of the Boruto series, Mitsuki stands as one of the most powerful ninjas that Konoha has. Mitsuki has access to powerful Sage Transformation, as well as advanced genetics thanks to experimentation by Orochimaru. Mitsuki is an incredibly powerful ninja who can even hold his own against Boruto Uzumaki to a certain extent. While he's not as strong as Boruto, he is still far stronger than the average Kage.
In fact, the acting Hokage of Konoha, Shikamaru Nara, isn't all that strong, and Mitsuki can easily deal with him in combat.
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