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Antihypertensive medications combined into a single pill lowered blood pressure more effectively than typical treatment with multiple pills for patients in Jamaica and Colombia, a study co-led by UT Southwestern Medical Center researchers shows.

The findings, shared during the Late-Breaking Science presentations at the 2026 American Heart Association Scientific Sessions held in Chicago Nov. 6–9 and published concurrently in JAMA, establish the long-term effectiveness and safety of this approach for treating uncontrolled high blood pressure.

"Our study demonstrated that a single-pill combination provided an effective, implementable, scalable and sustainable approach for hypertension control in low- and middle-income countries," said Jiang He, chair of epidemiology in the Peter O'Donnell Jr. School of Public Health and professor of internal medicine and neurology at UT Southwestern.

"It improves patients' adherence to medication and satisfaction with medication and hypertension-related care. The trial also provides additional evidence for physicians to recommend this treatment to patients with high blood pressure in the U.S. and beyond."

High blood pressure, also known as hypertension, is the leading preventable risk factor worldwide for a bevy of conditions including cardiovascular disease, chronic kidney disease, stroke and dementia, as well as for death from any cause. Although the prevalence of hypertension has decreased in high-income countries over the past several decades, it has increased in low- and middle-income countries.

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