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Nearly 3 in 4 couples with unexplained infertility have a baby within two years of starting treatment

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Nearly 3 in 4 couples with unexplained infertility have a baby within two years of starting treatment

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A new study has found nearly 3 out of 4 couples with unexplained infertility had a baby within two years of starting treatment, whether they received in vitro fertilization (IVF) or intrauterine insemination (IUI). While IVF led to faster pregnancies, long-term outcomes were similar for both treatments.

The seven-year national trial was led by researchers at Waipapa Taumata Rau, University of Auckland, and supported by six fertility clinics across New Zealand. One of the largest studies of its kind, it followed 737 couples struggling to conceive despite tests showing no obvious cause. The findings are published in the New England Journal of Medicine.

Couples were randomly assigned to one of two treatment pathways. One group began with intrauterine insemination (IUI) and progressed to in vitro fertilization (IVF) if they did not become pregnant, while the other group proceeded directly to IVF. IUI involves placing prepared sperm directly into the uterus at the time of ovulation. IVF involves collecting eggs, fertilizing them in a laboratory and transferring an embryo into the uterus.

The study found IVF offered the best chance of having a baby sooner, but both approaches produced virtually the same outcome after two years.

A single cycle of IVF resulted in a live birth for about half of the participants, compared with about one-third of those who underwent four cycles of IUI.

"We found that IVF resulted in more live births, so approximately one in two couples would end up with a baby after doing one cycle of IVF, compared to one in three with IUI," says Dr.


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