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Gene expression linked to survival differs by kidney cancer subtype

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Gene expression linked to survival differs by kidney cancer subtype

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Renal cell carcinoma (RCC) is the most common form of kidney cancer, accounting for about 90% of kidney cancers. It develops when abnormal cells in the kidney's small tubules begin to grow uncontrollably. RCC has several subtypes that differ in their origin, molecular characteristics and genetic makeup.

Among them, clear cell RCC (ccRCC) and papillary RCC (pRCC) are two common subtypes, accounting for approximately 80% and 10%–15% of RCC cases, respectively. The two subtypes differ in their appearance, with ccRCC typically showing clear-looking cancer cells and pRCC forming fingerlike structures called papillae. However, molecular markers that can reliably help assess prognosis in these subtypes remain limited.

Now, by analyzing publicly available cancer databases, researchers at Tokyo University of Science (TUS), Japan, and Nippon Medical School, Japan, have found that high expression of a gene called CTD nuclear envelope phosphatase 1 (CTDNEP1) is associated with poorer survival outcomes in patients with ccRCC.

The study was led by professor Tadayoshi Hayata at TUS and conducted by first author Mayuka Nii, a Ph.D. candidate at TUS, together with Kazutaka Ota, who was a third-year medical student at Nippon Medical School at the time of the study. Ota participated through Nippon Medical School's "Project Semester III" research placement course, which provides students with hands-on research experience under faculty supervision. This cross-institutional collaboration was a key aspect of the study.



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